http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2017166910-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_6cd34faa00e03e93f82f3f79fe2ee0e0 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-1051 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y204-01232 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-815 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-2488 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y302-0113 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-81 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-24 |
| filingDate | 2017-02-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4006c9b42e9c74116bb4ea9a3a637c7b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_64ddb605599243ca643e5e52167928d1 |
| publicationDate | 2017-06-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-2017166910-A1 |
| titleOfInvention | Pichia pastoris strains for producing predominantly homogeneous glycan structure |
| abstract | Disclosed herein are novel Pichia pastoris strains for expression of exogenous proteins with substantially homogeneous N-glycans. The strains are genetically engineered to include a mutant OCH1 allele which is transcribed into an mRNA coding for a mutant OCH1 gene product (i.e., α-1,6-mannosyltransferase, or “OCH1 protein”). The mutant OCH1protein contains a catalytic domain substantially identical to that of the wild type OCH1 protein, but lacks an N-terminal sequence necessary to target the OCH1 protein to the Golgi apparatus. The strains disclosed herein are robust, stable, and transformable, and the mutant OCH1 allele and the ability to produce substantially homogeneous N-glycans are maintained for generations after rounds of freezing and thawing and after subsequent transformations. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11220692-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109082444-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10612033-B2 |
| priorityDate | 2012-10-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 911.