| abstract |
Compounds of the formula n (Z) x wherein: each Z is independently selected from 2′-deoxythymidinyl moiety, 2′-deoxyadenosinyl moiety, and a 2′-deoxycytidinyl moiety, x is an integer from 5-20, wherein said 2′-deoxythymidinyl moieties are connected by thiophosphate triester linkages, and 3-12 of said thiophosphate triester linkages being positively charged linkages of the formula: n n n n n n n n n n n n where n is an integer from 2 to 6; and the remainder of the thiophosphate triester linkages are neutral linkages of the formula: n n n n n n n n n n n n n n n n provided that when x is 5-6, the number of positively charged linkages is 3, when x is 7-8, the number of positively charged linkages is 3-4, when x is 9-12, the number of positively charged linkages is 3-10, and when x is 13-20, the number of positively charged linkages is 4-12. |