http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2017121425-A1

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filingDate 2015-06-16-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d8a810b59d6ec6b494585fafc927e4ea
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publicationDate 2017-05-04-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber US-2017121425-A1
titleOfInvention HUMANIZED ANTI-IgE ANTIBODIES THAT CROSSLINK CD23 ON B LYMPHOCYTES BUT DO NOT SENSITIZE MAST CELLS
abstract A novel humanized anti-IgE antibody is disclosed. The antibody is capable of binding to free IgE, membrane-bound IgE on B lymphocytes, IgE bound by CD23, but not to IgE bound by high-affinity IgE.Fc receptor on mast cells. The present invention relates to the treatment of IgE-mediated diseases, including allergic asthma, allergic rhinitis, atopic dermatitis, food allergy, chronic spontaneous (idiopathic) urticaria, chronic rhinosinusitis, systemic mastocytosis, cutaneous mastocytosis, allergic bronchopulmonary aspergillosis, recurrent idiopathic angioedema, and eosinophil-associated gastrointestinal disorder by administering the anti-IgE antibody of the present invention.
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priorityDate 2014-06-17-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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