Predicate |
Object |
assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_3de53a7f78e5e584d003216ae45372be http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_eb258be6a48fd6826b8c923ea4234dff |
classificationCPCAdditional |
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classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-0602 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-68 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5005 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-0672 |
classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-071 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-074 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-0789 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-68 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-50 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P1-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K35-48 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K35-12 |
filingDate |
2016-10-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_233f7aae3e2eab13389519c167588d2a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4fef5acd8c7212cd5f5b93341a760952 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_339efa044ca03ff877ef47ce9a5014ff http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6121c5ae73314b98996d1f0391dd9be4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6a902d4fcd2bdf779bb77d6434c4ccbd |
publicationDate |
2017-04-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber |
US-2017096641-A1 |
titleOfInvention |
Primitive and proximal hepatic stem cells |
abstract |
Hepatic progenitors comprise two populations of human hepatic stem cells, primitive and proximal hepatic stem cells, and two populations of committed progenitors, one for biliary cells and one for hepatocytes. Human primitive hepatic stem cells are a very small fraction of the liver cell population and give rise to proximal hepatic stem cells constituting a much larger fraction of the liver. Human proximal hepatic stem cells give rise to biliary and hepatocyte committed progenitors. Primitive and proximal stem cells are the primary stem cells for the human liver. Human primitive hepatic stem cells may be isolated by immunoselection from human livers or culturing human liver cells under conditions which select for a human primitive hepatic stem cell. Proximal hepatic stem cells may be isolated by immunoselection, or by culturing human liver cells under conditions which include a developmental factor. Proximal hepatic stem cells may also be isolated by culturing colonies comprising a primitive hepatic stem cell under conditions which include a developmental factor. Resulting compositions may be used for treating liver disorders and for producing bioartificial organs. |
priorityDate |
2002-03-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type |
http://data.epo.org/linked-data/def/patent/Publication |