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publicationDate 2017-03-23-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber US-2017082625-A1
titleOfInvention Method and system for microfilter-based capture and release of cancer associated cells
abstract A slotted microfilter is coated with a phase changeable material having a hydrophobic state under a first temperature and a hydrophilic state under a second temperature. An example coating material is poly(N-isopropylacrylamide) (“PIPAAm”). The microfilter can be controlled to switch between a capture state where circulating tumor cells are captured by the microfilter and a release state, where viable tumor cells are released from capture for analysis, e.g., single cell phenotypic and genomic analysis, or for ex vivo culture growth.
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