http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2017079972-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_72046362a91a0f0277abe5495e47790f |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4743 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4743 |
| filingDate | 2015-10-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d9e6bef4649a7c3ce92d3b8fc03fff4a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_52d59ae320e2fc5082eaab2e9b9d69f2 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_53c68fcf84ecf0727d6b0af2951e9723 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8295b7fb2647c506eb38b2338b1dc184 |
| publicationDate | 2017-03-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-2017079972-A1 |
| titleOfInvention | Novel ros1 inhibitor and its use |
| abstract | The administration of a compound advantageously efficacious as ROS1 inhibitor and its effect on subjects with cancer includes administering a compound having certain structural components such as a quinoline moiety in the backbone and at least one tertiary amine containing moiety in a side chain as well as heteroatoms, in particular oxygen atoms, present in the backbone and the side chain for treating a subject suffering from a disease such as cancer. The presence of such structural components allows for an advantageous interaction with the ROS1 kinase domain, in particular with the hinge region. The administered compounds represent a highly promising opportunity in particular for patients bearing ROS1-dependent cancer. A method for targeting tumor cells harboring an abnormality in ROS1 gene includes contacting a cell with compounds of the present invention as well as pharmaceutical compositions comprising such compounds. |
| priorityDate | 2015-09-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 229.