http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2017059595-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2a819eda0adf22936a52362eeebb9fb4 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2333-904 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2800-50 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2800-323 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2333-908 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G16H10-60 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-92 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G06F19-322 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N21-6428 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G06F19-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-92 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N21-64 |
| filingDate | 2015-02-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5a4d7a3faf3b728a1ce3be1987db8c59 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e3d4960bcbbfcc8eaddfb32fbe3c9782 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9191c74006caf593b540362d97176f63 |
| publicationDate | 2017-03-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-2017059595-A1 |
| titleOfInvention | High throughput biochemical fluorometric method for measuring hdl redox activity |
| abstract | In various embodiments, a new, robust fluorometric cell-free biochemical assay that measures HDL redox activity (HRA) is provided. In certain embodiments the assay is based on the oxidation of the fluorochrome AMPLEX® RED in the presence of HRP. HRA correlated with previously validated cell-based (r=0.47, p<0.001) and cell-free assays (r=0.46, p<0.001). HRA measurement identified samples with dysfunctional HDL in established animal models of atherosclerosis and Human Immunodeficiency Virus (HIV) patients. Using an immunoaffinity method for capturing HDL the utility of this novel assay for measuring HRA in a high throughput format was demonstrated. HRA measurements correlated significantly with measures of cardiovascular disease such as carotid intima media thickness (r=0.35, p<0.01) and subendocardial viability ratio (r=−0.21, p=0.05) and physiological parameters such as metabolic and anthropometric parameters (p<0.05). This new fluorometric method that offers a reproducible and rapid means for determining HDL function/quality that is suitable for high throughput implementation. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2022076884-A1 |
| priorityDate | 2014-02-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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