| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_5d99cde358eae07705f1378640ed55df |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2720-12064
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2720-12232
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2720-12264
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2720-12032 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N7-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K35-765
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K45-06 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N7-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K45-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K35-765 |
| filingDate |
2016-08-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_85cd57d80fb77979e367f72a7ae247f5
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1a913a9ee3752c4591241afb01fac425 |
| publicationDate |
2017-02-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2017049829-A1 |
| titleOfInvention |
Attenuated reovirus |
| abstract |
Compositions and methods are provided that relate to an attenuated reovirus exhibiting oncolytic activity toward cancer cells while displaying reduced lytic activity toward non-malignant cells. Exemplified is an attenuated human reovirus derived from persistently infected fibrosarcoma cells that lacks wild-type reovirus S1 and S4 genes and consequently lacks a detectable reoviral outer capsid .sigma.1 protein and expresses a mutated reoviral outer capsid .sigma.3 protein. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2018218137-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2022081426-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2020237050-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2022026496-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10260049-B2 |
| priorityDate |
2005-08-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |