http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2017038395-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_85ed0fe39341bca701071d8c6734c447 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-515 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2509-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-5154 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-5158 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2333-70517 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-0637 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-56972 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-6872 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K35-17 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-569 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-68 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-0783 |
| filingDate | 2015-04-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_82435a08c9f95b2a88eb689362757fb3 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_22b8b47afa632cc341a6cbb444b4726f |
| publicationDate | 2017-02-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-2017038395-A1 |
| titleOfInvention | Cd8+ regulatory t-cells for use in the treatment of inflammatory and autoimmune diseases |
| abstract | The present invention relates to a method for identifying CD8 + Treg cells suitable for use as starting material in cellular immunotherapy, the method comprising i) analysing samples from target tissue A to identify CD8 + Treg cells with migratory character between the diseased tissue, collecting lymphatics, peripheral blood, distinct tissue adjacent to the diseased target tissue A and/or distinct tissue that is not vicinal though has migratory Treg communication with target tissue A, v) analysing samples from peripheral blood, tissue C, to identify CD8 + Treg cells with migratory character and/or functional character where the Treg cells are also emigrant from target tissue A, vi) analysing sample(s) from tissue compartments A and/or B and C, that are analytically or physically depleted of emigrants from thymus and/or immigrants from peripheral blood to a lymph node, to restrict analyses to CD8 + Treg cells of target tissue A origin and/or tropism, to identify emigrant CD8 + Treg cell populations of target tissue A, to identify emigrant CD8 + Treg cell populations with propensity to immigrate to target tissue A, to identify a migratory and/or functional defect in the CD8 + Treg cell population identified as expressing migratory and/or functional elements specific for target tissue A in any of tissue A, B or C, and whereby a combination of surface or intracellular markers on CD8 + Treg cells is identified, which combination identifies which surface or intracellular markers should be present and which surface markers should not be present in CD8 + Treg cell populations suitable for use as starting material in cellular immunotherapy. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10758568-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113826014-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10646515-B2 |
| priorityDate | 2014-04-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 50.