| abstract |
Macrocyclic benzodiazepine dimers having a structure represented by formula I n n n n n n n n n n where A and B are independently according to formulae Ia or Ib n n n n n n n n n n and the other variables in formulae I, Ia, and Ib are as defined in the application. Such dimers are useful as anti-cancer agents, especially when used as the drug component in an antibody-drug conjugate (ADC). |