| abstract |
The present invention relates to molecules of formula (I) where R1=—SO 3 H, —PO 3 H, —PO 2 (OH) 2 , —OPO 2 H 2 , —NHSO 3 H, —S(N═H)Me, SH, SR or guanidyl; R═C 1-4 alkyl, phenyl or 5 or 6 membered aromatic nitrogen heterocycles; n=1, 2, 3, 4 or 5; X═C=0, C(OH)H, C(OAlk)H, C═S, CH 2 ; Alk=C 1-6 alkyl linear, branched or cyclic, optionally hydroxylated or polyhydroxylated; their preparation and use as analgesics and in the treatment of pain induced by chemotherapies. |