| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_25c76b5b8293c2914fadced494084bcf |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C271-34
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C271-22
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-533
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-582 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C271-22
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C271-34
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-58 |
| filingDate |
2015-01-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1bc0ad9fc46d2dda0fd7c5ae07ffc0de
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0e1c42ef59fc540352d28d7e571fda09
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_40563bf341631b938b5d483064b3b315
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9a3db17fd24267f41f9d5dd6f4caa6d2
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b32f7f72f25299b4e039d8e582c8275d
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_dcc08bfaa0e966d0e622a6557063b5c9 |
| publicationDate |
2016-11-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2016340297-A1 |
| titleOfInvention |
Multiple cycloaddition reactions for labeling of molecules |
| abstract |
The present invention relates to methods for linking tetrazines with dienophiles to establish at least two linkages by sequentially performing at least two cycloaddition reactions. The methods in particular allow establishing multi-labeling strategies. In particular, the invention relates to methods for forming linkages by cycloaddition reactions, wherein the method comprises reacting a first alkyl-substituted tetrazine with a first dienophile comprising a irans-cyclooctenyl group followed by reacting a second tetrazine with a second dienophile comprising a cyclooctynyl group, wherein the reaction of the first tetrazine with the first dienophile proceeds in the presence of the second dienophile. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10975186-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10822447-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11345963-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2019338354-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2021003258-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11492608-B2 |
| priorityDate |
2014-01-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |