http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2016331752-A1

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filingDate 2016-07-22-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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publicationDate 2016-11-17-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber US-2016331752-A1
titleOfInvention Risperidone sustained release microsphere composition
abstract A risperidone sustained release microsphere formulation is provided. The microsphere formulation includes risperidone or 9-hydroxy risperidone or salts thereof, and a polymer blend having a first uncapped lactide-glycolide copolymer and a second uncapped lactide-glycolide copolymer, in which the first uncapped lactide-glycolide copolymer is a copolymer with a high intrinsic viscosity and the second uncapped lactide-glycolide copolymer is a copolymer with a low intrinsic viscosity. The sustained release micro sphere formulation according to an embodiment of the present disclosure is suitable for large-scale industrialized production with improved stability, the in vivo release behavior of which will not change after long-term storage.
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