| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_8fe334aa198e9d25729a42af99ed8bf3 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-51
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-515
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-56
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-565 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-40
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-1037
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-005 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-40
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-10 |
| filingDate |
2016-05-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5f69945b6c24ef43d756ee28eb8b014f
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_933371056ec56e6f7a8595efe6b8c8b7
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_429e6dcea25acc58b3819c9b8773e183 |
| publicationDate |
2016-11-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2016318995-A1 |
| titleOfInvention |
Randomized Humanized Antibody Libraries Engineered with Sequence and Insert Diversity |
| abstract |
A phage display library is formed by a plurality of recombinant phages; each of the plurality of recombinant phages comprising an M 13 -derived expression vector; the M 13 -derived expression vector comprising a polynucleotide sequence encoding a randomized peptide, wherein the randomized peptide is a variable region of a human IgG 1 heavy chain; the randomized peptide is expressed in absence of an immunoglobulin light chain protein on an outer surface of a recombinant phage of the phage display antibody library; and a protein product expressed by a recombinant phage of the phage display antibody library fuses with a human immunoglobulin constant region to form a full human IgG 1 heavy chain molecule. The phage display library can be utilized to identify candidate antibodies that can bind to receptor Axl and other receptors. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113354735-A |
| priorityDate |
2015-05-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |