| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1c8cbbf2290b3f3a9988da29598baa2c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_bf29ec5744d8fa824fb8b2b21adfabb9 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-76
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-14 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-113
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-3092
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-3069
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-3015
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-30
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-18
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5011 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-30
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-18
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-50
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-113 |
| filingDate |
2016-03-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_be3f76b927dd214863e225dc47b2caec |
| publicationDate |
2016-10-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2016289311-A1 |
| titleOfInvention |
Compositions and methods for treating cancer by rational targeting of protein translation |
| abstract |
The present invention is drawn to therapeutics which can target hnRNP A18, a regulator of protein translation in cancer cells. The invention provides a method of treating cancer in a subject comprising administering to the subject a therapeutically effective amount of a composition that decreases the level and/or activity of heterogenous ribonucleoprotein A18 (hnRNP A18). The composition can comprise a nucleic acid molecule that binds to at least a portion of a nucleotide sequence coding for hnRNP A18. The invention also provides a composition for treating cancer comprising a nucleic acid or antibody that is capable of decreasing the level and/or activity of hnRNP A18 and a pharmaceutically acceptable carrier. The invention also provides methods of screening for an anti-cancer compound. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10287353-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10385130-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10385131-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11510908-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11535670-B2 |
| priorityDate |
2015-03-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |