| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_b12f0d44fedff92f970fb40a547058be
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ceb16dd5c50b42d356bc14635df4bfb6 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2800-042
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-158
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-136
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2500-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2333-723 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6876
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5041
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-507
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-502
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5023
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5014
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-573 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-573
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-68
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-50 |
| filingDate |
2014-11-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_87f588258da6c76397b328d4471bc0bc
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5463ccf21fcd6183656be7ffadb76b08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3a3c7297ae5bd9ed19210fb4db4ffdae
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_23ccc546695456a0c93f97afb1ea5af4 |
| publicationDate |
2016-09-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2016274087-A1 |
| titleOfInvention |
Screening assay for agents that influence beta cell number and/or phenotype |
| abstract |
The present invention in general relates to a method for identifying compounds that influence beta cell number and/or phenotype, more in particular beta cell differentiation, proliferation and/or expansion. Said method comprising culturing beta cells or precursors thereof in 5 medium comprising glucose, and determining the ability of said compound to induce the glucocorticoid receptor dependent-transactivation pathway in said beta cells. It further relates to compounds identified in such methods, and uses of said compounds as positive controls in methods for identifying compounds that influence beta cell number and/or phenotype; or uses thereof in the treatment of pathologies characterized by changes in beta-cell number and/or 10 phenotype such as for example diabetes mellitus. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11033666-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11642501-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11701215-B2 |
| priorityDate |
2013-11-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |