| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_3110670ae97dbadd8800fa3d5b82687c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_8d36a5393ba2d34a292205901b92681e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_7b54d6a7a93af91aa896438f48ce0119
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_650117e2693fdc2544fb198ed945c865 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-3515 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-543
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-554
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-1136
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-713
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K48-0058
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P21-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P21-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-48123 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-113
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-48
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K48-00 |
| filingDate |
2014-11-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2c61d333401ae9cbed32df1229df1aeb
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0eff582d4518f60ca52dfcd155a2fd94
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9bb3d9f24add12eed6de7cce9fa784b3
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a12aaef83db8a15c29f9f737b2c5f447
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_04e85c566873fe2aa0012b3f3e559637
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_947049e16fb775a8f29a373467bc7ea6 |
| publicationDate |
2016-09-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2016256570-A1 |
| titleOfInvention |
SYSTEMIC DELIVERY OF MYOSTATIN SHORT INTERFERING NUCLEIC ACIDS (siNA) CONJUGATED TO A LIPOPHILIC MOIETY |
| abstract |
The present invention provides methods comprising the in vivo delivery of small nucleic acid molecules capable of mediating RNA interference and reducing the expression of myostatin, wherein the small nucleic acid molecules are introduced to a subject by systemic administration. Specifically, the invention relates to methods comprising the in vivo delivery of short interfering nucleic acid (siNA) molecules that target a myostatin gene expressed by a subject, wherein the siNA molecule is conjugated to a lipophilic moiety, such as cholesterol. The myostatin siNA conjugates that are delivered as per the methods disclosed are useful to modulate the in vivo expression of myostatin, increase muscle mass and/or enhance muscle performance. Use of the disclosed methods is further indicated for treating musculoskeletal diseases or disorders and/or diseases or disorders that result in conditions in which muscle is adversely affected. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2022056277-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10933081-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-4035659-A1 |
| priorityDate |
2013-11-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |