http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2016244441-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_966a6c1f382ec9bcb5e3839dfd73e5b8 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-437 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K49-0002 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K49-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K49-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-04 |
| filingDate | 2015-10-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_520f33558afc03a605e7c82123805a40 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_94db340f489be26a21d28a776465b728 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_71a09f7b6ded4abf20af4878000b8829 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d1587176c842f346fcdb10c856e049df http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bbac162bb593d4df4c38029729b259d1 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6d361c8cd448909c6953bdb08cd51e78 |
| publicationDate | 2016-08-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-2016244441-A1 |
| titleOfInvention | 2-PHENYL OR 2-HETARYL IMIDAZOL[1,2-a]PYRIDINE DERIVATIVES |
| abstract | The invention relates to compounds of formulas I and II n n n n n n n n n n whereinn R 1 is hydrogen, lower alkyl, lower alkoxy, halogen, S-lower alkyl, lower alkoxy substituted by halogen, di-lower alkyl amino, C(O)O-lower alkyl, lower alkyl substituted by hydroxy or hydroxy; R 2 is hydrogen, lower alkyl, halogen, lower alkoxy, S-lower alkyl, lower alkoxy substituted by halogen, O(CH 2 ) 2 -lower alkoxy substituted by halogen, di-lower alkyl amino, alkyl amino, NH-lower alkyl substituted by halogen, N(lower alkyl)-benzyl, lower alkyl substituted by hydroxy, heterocycloalkyl optionally substituted by halogen, CH 2 -lower alkoxy, CH 2 -lower alkoxy substituted by halogen or hydroxy; or R 1 and R 2 form together with the carbon atoms to which they are attached a ring containing —OCH 2 CH 2 O—, OCH 2 O—, OCH 2 CH 2 CH 2 O— or —NHC(O)CH 2 O—; R 3 is hydrogen or lower alkoxy; R 4 is hydrogen or lower alkyl; R 5 is lower alkyl, cycloalkyl, lower alkyl substituted by hydroxy or lower alkyl substituted by halogen; or R 4 and R 5 form together with the nitrogen atom to which they are attached a ring containing —CH 2 CH 2 CHRCH 2 CH 2 —, —CH 2 CHRCH 2 CH 2 —, —CH 2 CH 2 OCH 2 CH 2 —CH 2 CH 2 NR′CH 2 CH 2 —, CH 2 CHR— or —CH 2 CH 2 CH 2 —; whereinn R is hydrogen, halogen, lower alkyl, lower alkoxy or lower alkyl substituted by halogen; R′ is lower alkyl substituted by halogen; n R a is hydrogen or 3 H; R b is hydrogen, hydroxy or 3 H; R 6 is hydrogen, halogen or lower alkyl; HetAr is selected from the group consisting of thiophenyl, furanyl, thiozolyl, benzofuranyl, pyrazolyl, benzoimidazolyl or pyridinyl; n is 1 or 2; or to a pharmaceutically acceptable acid addition salt, to a racemic mixture or to its corresponding enantiomer and/or optical isomers thereof. nn The present compounds are suitable as imaging tool, which will improve diagnosis by identifying potential patients with excess of tau aggregates in the brain, which may be likely to develop Alzheimer's disease. |
| priorityDate | 2013-04-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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