http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2016243201-A1
Outgoing Links
Predicate | Object |
---|---|
assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_5be1d27acf8a63f82dff0177ddaf7fae |
classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-40 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-79 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-0019 |
classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-40 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-00 |
filingDate | 2014-11-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_21e2e17a8884c12a794c171f89c5b18e |
publicationDate | 2016-08-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber | US-2016243201-A1 |
titleOfInvention | Methods and compositions for increasing hepcidin expession using modified iron binding/releasing transferrin |
abstract | Provided are methods for increasing hepcidin expression, treating a disorder associated with iron overload, decreasing non-transferrin bound iron (NTBI), reducing spleen size, ameliorating ineffective erythropoiesis, decreasing iron uptake by erythroid cells, and increasing transferrin receptor 1 (TfR1) expression in a subject in need thereof, comprising administering to said subject a therapeutically effective amount of a modified iron binding/releasing transferrin, wherein said modified iron binding/releasing transferrin comprises an N-lobe and a C-lobe, and wherein one of said lobes binds iron, and wherein one of said lobes has a decreased binding affinity for iron. |
isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10364239-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11001579-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10738041-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11129820-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11066399-B2 |
priorityDate | 2013-11-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 1229.