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filingDate 2014-08-22-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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publicationDate 2016-08-04-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber US-2016223563-A1
titleOfInvention Diagnostic tests and methods for assessing safety, efficacy or outcome of allergen-specific immunotherapy (sit)
abstract The present invention provides in vitro and in vivo diagnostic tests and methods for determining the safety, efficacy, or outcome of allergen-specific immunotherapy (SIT) in a patient. The present invention also provides for the measurement of allergen specific IgG and IgE in a patient tissue sample, or extract thereof, or in a biological fluid or blood sample, and determining whether the allergen-specific immunoglobulins contained in the patient sample(s), upon injection into an allergen-sensitized animal, will protect the animal following challenge with the allergen. The invention also provides methods for determining whether a patient suffering from an allergy is responsive to therapy with one or more therapeutic antibodies specific for the allergen.
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