| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_6cb0a0d1228f358ca0b7fece8279a795
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c6c6b8507cc886874ce1f3dae8f6e9d4
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d8a219eb07af9fcec1e268bf3966e735 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2333-445
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2469-20
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02A50-30 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-6854
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-015 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-68
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-015 |
| filingDate |
2014-09-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_34f4fe41f0e5b6a2c3383bd54a844a5c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d26c376d00f2dc1a6c63ef498a1894ce
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6d58759eb639a0f9e5ed428b91f730f6 |
| publicationDate |
2016-07-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2016216276-A1 |
| titleOfInvention |
Serum antibody assay for determining protection from malaria, and pre-erythrocytic subunit vaccines |
| abstract |
Disclosed herein are diagnostic assays for identifying individuals that are protected against Plasmodium falciparum caused malaria. Such assays are particularly useful for determining not only the protective efficacy of Pf whole parasite vaccines for individual subjects, but also within populations of vaccinated subjects. The assays comprise the use of proteomes representing at least 50% of Pf, preferably coupled to a solid phase as a fixed array. The arrays are used to probe the sera of human subjects, particularly subjects of human clinical trials of whole parasite malaria vaccines as well as public health vaccination campaigns. Serum samples with antibody profiles most strongly reactive in multiplex to CSP and MSP5 demonstrate a sensitivity of from 92% to 100% and a specificity of from 84% to 89%. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11207395-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9642909-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10197577-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10441646-B2 |
| priorityDate |
2013-08-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |