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filingDate 2016-04-05-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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publicationDate 2016-07-21-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber US-2016207967-A1
titleOfInvention Phl p 5a derivatives having reduced allergeneity and retained t-cell reactivity
abstract The present invention relates to the preparation and use of variants of the group 5 allergen of the Pooideae which are characterised by reduced IgE reactivity compared with the known wild-type allergens and at the same time by substantially retained reactivity with T lymphocytes. These hypoallergenic allergen variants can be employed for the specific immunotherapy (hyposensitisation) of patients having grass pollen allergy or for the preventative immunotherapy of grass pollen allergies.
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