| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1c89ce4d9ac03f9acd8ddede1162f94d |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K45-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D405-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D405-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-616
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4365
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-444
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-443 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K45-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D405-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D405-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-443
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-444 |
| filingDate |
2014-08-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f6c4663a9d29368600f015069db4c598
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_66a169a136a4e5453cb0d7a26187cbd3
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8d8cf1290d9800f84ca429b882b69f65
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0d3fa8fa7a5098f7c657208155faacf7
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b0dbe9bfe4cad11c27cf6fc1ac586535 |
| publicationDate |
2016-06-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2016185764-A1 |
| titleOfInvention |
Preparation and use of 7a-amide substituted- 6,6-difluoro bicyclic himbacine derivatives as par-1 receptor antagonists |
| abstract |
The present invention relates to bicyclic himbacine derivatives of the formula n n n n n n n n n n n n or a pharmaceutically acceptable salt thereofn nwherein:n n R 1 is —[C(R a )(R b )] x —[C(R b )(R b )] y —C(O)NH 2 , or —N(H)—[(CH 2 )] z —C(O)—NH 2 , n W is n n n n n n n n n n n n n n and the remaining variables are described herein. The compounds of the invention are effective inhibitors of the PAR-1 receptor. The inventive compounds may be used for the treatment or prophylaxis of disease states such as ASC, secondary prevention of myocardial infarction or stroke, or PAD. |
| priorityDate |
2013-08-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |