http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2016151466-A1

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publicationDate 2016-06-02-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber US-2016151466-A1
titleOfInvention Botulinum neurotoxins with modified light chain specifity and methods for producing same
abstract A protease directed to a non-neuronal SNARE protein is described. The protease is produced by selective mutation of a botulinum neurotoxin light chain, and is characterized utilizing a reporting construct that includes all or part of the non-neuronal SNARE protein. Such a protease has utility in the treatment of diseases associated with hypersecretion, where the hypersecretion is mediated by a non-neuronal SNARE protein.
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