| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_eaa5b3209217b413da83f6e01f4ac6fa |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2800-72 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K8-987
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K35-63
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K35-64
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61Q19-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61Q19-08 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K8-98
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61Q19-08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61Q19-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K35-64 |
| filingDate |
2013-06-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ca5c63aab92ab97fd621b1c2ea5bf658
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5aa209ce561e011878969bb8a532ef28
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_37950006a136f94e79754a50cd504c4e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d370aec302798fe9f6ba07048ee6f3b0
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f21fd58495496cf4245efc78ad81f53c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_837b59dc70950c608710ac73e12e41bf
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e5cae578a435a0d98f112ddb75567a40
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5f2bfc164785b3512a7a4457774dc827
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_33aa5f114ff764260160df84c73e915d |
| publicationDate |
2016-06-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2016151426-A1 |
| titleOfInvention |
Preparation of bee venom with allergenic components removed |
| abstract |
Disclosed is a method for manufacturing a separated and purified bee venom (separated PBV) not possessing allergy-triggering effects by reducing or eliminating allergy-inducing components contained in a bee venom via ultrafiltration, thereby producing a PVB with desirable pharmacological effects while fundamentally blocking allergies that may be induced by the same. The manufacturing method of the present invention includes a first step of preparing a purified bee venom powder; a second step of preparing a bee venom liquid by mixing the purified bee venom powder with distilled water; a third step of removing allergic ingredients contained in the bee venom liquid via ultrafiltration through a membrane having a cut-off size of 10 kDa; and a fourth step of obtaining a separated PBV with the allergenic components removed; wherein the distilled water to be mixed with the purified bee venom powder in the second step is used in the range of from 1000 mL to 1500 mL per 1 g of the purified bee venom powder, the allergenic components removed through the ultrafiltration membrane in the third step are phospholipase A2 and hyaluronidase, and the separated PBV obtained in the fourth step contains 4 wt % or higher of apamin, and 50 wt % or higher of melittin. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113768957-A |
| priorityDate |
2013-06-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |