http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2016144026-A1

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filingDate 2015-11-25-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1c5115ac793e5bd691dfd2c5a499f559
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publicationDate 2016-05-26-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber US-2016144026-A1
titleOfInvention Combination immunotherapy of antigen-recognizing receptors and hematopoietic cells for the treatment of diseases
abstract The invention provides a system that comprises pharmaceutical agents for use in immunotherapy for reducing the side-effects of an antigen-recognizing receptor against antigen-expressing non-target cells in an individual. The system includes an antigen-recognizing receptor that specifically recognizes an antigen on target cells and at least on one hematopoietic cell type in the individual. The antigen-recognizing receptor is exemplified by chimeric antigen receptors (CAR) be expressed on the surface of an immune effector cells. The system also includes hematopoietic cells resistant to recognition of the same antigen by the antigen-recognizing receptor.
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