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publicationDate 2016-05-26-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber US-2016144018-A1
titleOfInvention Methods of preparing anti-human papillomavirus antigen t cells
abstract Disclosed are methods of preparing an isolated population of human papillomavirus (HPV)-specific T cells comprise dividing an HPV-positive tumor sample into multiple fragments; separately culturing the multiple fragments; obtaining T cells from the cultured multiple fragments; testing the T cells for specific autologous HPV-positive tumor recognition; selecting the T cells that exhibit specific autologous HPV-positive tumor recognition; and expanding the number of selected T cells to produce a population of HPV-specific T cells for adoptive cell therapy. Related methods of treating or preventing cancer using the T cells are also disclosed.
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