| abstract |
The present invention is to provide a novel α-substituted glycinamide derivative, or a pharmaceutically acceptable salt thereof, a pharmaceutical composition comprising the same, and a pharmaceutical use thereof. n The present invention provides a compound represented by the general formula (I), which has TRPM8 inhibitory effects: n n n n n n n n n n [wherein A 1 represents a C 6-10 aryl and the like, A 2 represents a C 6-10 aryl and the like, X represents CH and the like, Y represents —CR 1 R 2 — and the like, R 1 and R 2 independently represent a hydrogen atom and the like, R 3 and R 4 independently represent a halogen atom and the like, n is 1 or 2], or a pharmaceutically acceptable salt thereof. Furthermore, the compound (I) of the present invention can be used as an agent for treating or preventing diseases or symptoms caused by hyperexcitability or disorder of afferent neurons. |