| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_18d92c46f60af8af24e262b67381d7eb |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D477-20
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P17-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P17-184 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D477-20
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P17-10 |
| filingDate |
2015-09-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b5d0acd761c05240915439f16b2d602c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b76ff1406cd71fa6aa0dda715474f926
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0a1d9098a05e4d3a7ee4e816e086f040
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_37914e623244eb05dbc1b9722584e96f |
| publicationDate |
2016-03-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2016083760-A1 |
| titleOfInvention |
Method for late introduction of the (8r) hydroxyl group carbapenem beta-lactam antibiotic synthesis |
| abstract |
The presently disclosed subject matter demonstrates that ThnG and ThnQ enzymes encoded by the thienamycin gene cluster in Streptomyces cattleya oxidize the C-2 and C-6 moieties of carbapenems, respectively. ThnQ stereospecifically hydroxylates PS-5 giving N-acetyl thienamycin. ThnG catalyzes sequential desaturation and sulfoxidation of PS-5, giving PS-7 and its sulfoxide. The ThnG and ThnQ enzymes are relatively substrate selective, but give rise to the oxidative diversity of carbapenems produced by S. cattleya , and orthologues likely function similarly in allied streptomyces. |
| priorityDate |
2009-12-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |