Predicate |
Object |
assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_85b959d2100bb308fcf773d125a37ab8 |
classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P19-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P19-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P19-44 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P21-005 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-1081 |
classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P19-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P19-18 |
filingDate |
2015-11-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7cbbd855f082da1e46475989536fd0d7 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_078e361b0c75e54721567bc18ff4b8c9 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_69459ee878c1dee14c5aa0715462ed1d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3c71c7af119e7dc7c4c6fcb04764b58c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1ef72f79ceed38b78304a101f46ae8c0 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_308f91c73d3127ac62d64283466e1cbe http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cef80033711823e0fa10deddd1a5123c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5a2d2d2c2ce933cbdab58b84b832722a |
publicationDate |
2016-03-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber |
US-2016076068-A1 |
titleOfInvention |
Quantitative control of sialylation |
abstract |
The present disclosure is directed to the use of certain glycosyltransferase variants having N-terminal truncation deletions. Contrary to previous findings certain truncations were found to exhibit sialidase enzymatic activity, particularly a variant of human sialyltransferase (hST6Gal-I) with a truncation deletion involving the first 89 N-terminal amino acids of the respective wild-type polypeptide. A fundamental finding documented in the present disclosure is that there exists a variant of this enzyme which is capable of catalyzing transfer of a glycosyl moiety as well as hydrolysis thereof. Thus, disclosed is a specific exemplary variant of mammalian glycosyltransferase, nucleic acids encoding the same, methods and means for recombinantly producing the variant of mammalian glycosyltransferase and use thereof, particularly for sialylating in a quantitatively controlled manner terminal acceptor groups of glycan moieties being part of glycoproteins such as immunoglobulins. |
isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2019010191-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11312936-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110914293-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11332771-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2019010531-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10927342-B2 |
priorityDate |
2013-05-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type |
http://data.epo.org/linked-data/def/patent/Publication |