| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_62f941494409aea84f621977c5f0ab81 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L2430-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L2400-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L2300-40 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08J3-075
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L27-52
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08B37-0084
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L27-20
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L27-38
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08L5-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08J3-246 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61L27-52
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61L27-38
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61L27-20 |
| filingDate |
2015-04-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_04b1770442fcbd91c635af0a0486a348
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_82e245177766100f2857b80f408766c4
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_945124aab8e223e68c689416b113bf8c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_dd20c052beadcdb3338d904c770539d1 |
| publicationDate |
2016-03-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2016074557-A1 |
| titleOfInvention |
Compositions and methods for modifying in vivo calcification of hydrogels |
| abstract |
Provided herein according to some embodiments of the invention are methods of inhibiting or preventing calcification of hydrogels. Such methods may include combining the hydrogel with a buffer solution having a pH lower than 7.4; forming hydrogel by crosslinking alginate in a solution comprising a bisphosphonate compound; and/or forming hydrogel by crosslinking polyanionic polymer with a polyvalent cation that is not Ca 2+ . Compositions that may be used in such methods are also provided herein. Also provided herein according to some embodiments of the invention are methods of bone regeneration and/or formation that include administering hydrogel that does not encapsulate biological material that affects calcification and/or bone formation to an area of a subject's body that is in need of bone formation and/or regeneration. |
| priorityDate |
2010-02-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |