| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_6816feeb907b38c9c94d6d966b067a4d |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01L2300-1827
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01L2300-0645
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01L2300-0816
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01L2300-0681 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01L9-527
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-86
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01L3-502715
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-4905 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-86 |
| filingDate |
2015-09-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2f3d6a49e3f76d0e8f81f393a9878253
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e1f00a0b79a63a531d60686d7e38a550
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3d6f4c74968482a4aaf76bc2b49f36f8
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b2b1256361443e13c49ea969f38689aa |
| publicationDate |
2016-03-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2016069913-A1 |
| titleOfInvention |
Microfluidic chip-based, universal coagulation assay |
| abstract |
A microfluidic, chip-based assay device has been developed for measuring physical properties of an analyte (particularly, whole blood or whole blood derivatives). The technologies can be applied to measure clotting times of whole blood or blood derivatives, determine the effects of anticoagulant drugs on the kinetics of clotting/coagulation, as well as evaluate the effect of anticoagulant reversal agents. These technologies can additionally be used to optimize the dosage of anticoagulation drugs and/or their reversal agents. The assay is independent of the presence of anticoagulant; clotting is activated by exposure of the blood sample in the device to a glass (or other negatively charged material such as oxidized silicon) surface, which activates the intrinsic pathway and can be further hastened by the application of shear flow across the activating materials surface. The absence of chemical activating agents and highly controlled and reproducible micro-environment yields a point of care universal clotting assay. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10989721-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2018013654-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2019099342-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2020529593-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-7214712-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2018204615-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10519493-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10852311-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109085367-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11413621-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10908171-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10228381-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11150255-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/TW-I684434-B
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2020027741-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10214772-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2020106556-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11371091-B2 |
| priorityDate |
2014-09-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |