| abstract |
The invention provides a molecule that modulates an activity of a Src family kinase for use in preventing or treating a metastatic cancer a subject. Preferably, the molecule comprises or consists of the structure: B j -[(Pro) n -X r -His-Pro-His-Ala-Arg-Ile-Lys] m -R p , or B j -[lys-ile-arg-ala-his-pro-his-x r -(pro) n ] m -R p , or a derivative or fragment thereof, wherein B is a first chemical moiety, j is 0 or 1, n is an integer from 1-10, X is any amino acid, r is an integer from 0 to 2, m is an integer from 1 to 3, R is a second chemical moiety, p is 0 or 1, and [lys-ile-arg-ala-his-pro-his-x r -(pro) n ] is the retro-inverso peptide of [(Pro)n-X r -His-Pro-His-Ala-Arg-Ile-Lys]. |