| abstract |
The present disclosure relates to pharmaceutical compositions with increased skin permeability for treating ear disease in mammals Disclosed pharmaceutical compositions are prepared as topical gels or as transdermal gels. The pharmaceutical compositions reduce ear inflammation and irritation produced by ear diseases or injuries (e.g., cauliflower ear, chronic otitis, and the like). The pharmaceutical compositions include a synergistic combination of pracaxi oil and seje oil. Additionally, the pharmaceutical compositions include phosphatidylcholine as a permeation enhancer. The combination of aforementioned natural components exhibits enhanced healing properties, thereby providing organic acids with antioxidant, antibacterial, and antifungal properties. The synergistic combination of pracaxi and seje oil increases the skin permeability to active pharmaceutical ingredients (APIs), thereby passing through the stratum corneum and reaching the target area; therefore, the dosage and time of treatment is significantly reduced. |