| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a2cd21ed4492119e6ec9d0c2bf7451b0 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-09
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-81 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P27-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-4702 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-47 |
| filingDate |
2014-04-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_14be5a63b09dfac7e9406fb759715001
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_47b5567449e6fdae76bda13cb3d7dce6
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6c5026cf3dcbc5f9be29fd22068b32e4 |
| publicationDate |
2016-02-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2016046682-A1 |
| titleOfInvention |
Artificial transcription factors engineered to overcome endosomal entrapment |
| abstract |
The invention relates to an artificial transcription factor comprising a polydactyl zinc finger protein targeting specifically a gene promoter, engineered to overcome endosomal entrapment after transduction into cells. Such artificial transcription factor comprises a polydactyl zinc finger protein fused to an inhibitory or activatory protein domain, a nuclear localization sequence, a protein transduction domain, and an endosome-specific protease-recognition site. These transducible artificial transcription factors are particularly useful for the treatment of diseases caused or modulated by membrane-bound receptor proteins, nuclear receptor proteins or products of haploinsufficient genes. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11530246-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11371023-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2020232366-A3
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113499335-A |
| priorityDate |
2013-04-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |