| abstract |
Imidazo[1,2-b]pyridazine-based compounds of the formula: n n n n n n n n n n are disclosed, wherein R 1 , R 2 and R 3 are defined herein. Compositions comprising the compounds and methods of their use to treat, manage and/or prevent diseases and disorders mediated by mediated by adaptor associated kinase 1 activity are also disclosed. |