| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ff81a650b70e913d3b2524b45e4c7320
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1bba710e7aaa56d8ab15a910fcd3dc5f |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2800-2814
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2800-50
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61B6-037
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G16H30-40
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61B2576-026 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-16
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K49-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K51-0491
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K49-0054
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K49-0032
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61B5-4064
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61B5-4082
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-6896
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-55
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-551
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-437
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61B5-055
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-28
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61M27-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-41
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4178 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61M27-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-68
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K49-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-55
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-551
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K51-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-41
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4178
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-437 |
| filingDate |
2014-02-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d8cd3ff345779a9c7813ce2a12a0af5d
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5de49fcd993ac03507b602acba30b25c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f03661343a0a66df5214e9939d7aaf65
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2e700e5279dcbb9a981bf47be51e0480 |
| publicationDate |
2016-01-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2016000945-A1 |
| titleOfInvention |
Methods for evaluating brain-wide paravascular pathway for waste clearance function and methods for treating neurodegenerative disorders based thereon |
| abstract |
Methods are provided for measuring glio-vascular pathway (“glymphatic system”) function in the brain of a mammal which include performing imaging of the brain and measuring cerebrospinal fluid-interstitial fluid (CSF-ISF) exchange in the brain. The methods can be used to track the exchange between CSF and ISF compartments. An imaging agent is optionally administered intrathecally. The imaging agent can be a negative or positive (paramagnetic) contrast agent and dynamic or contrast-enhanced magnetic resonance imaging (MRI) of the brain can be performed. The imaging agent can be a positron-emitting radionuclide tracer and positron emission tomography (PET) can be performed. Methods for treating diseases or disorders of the mammalian brain are also provided, in which the methods increase or decrease glymphatic clearance. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10792246-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2021215781-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-D861038-S
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11426577-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2023023170-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10765382-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2021069343-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11517524-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11497711-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2021207457-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2019157119-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11478422-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11559484-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11786508-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2021256691-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2022155358-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11096643-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11559626-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2017223092-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2018129891-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11474180-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11727571-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2020014394-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2023073526-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2018015467-A1 |
| priorityDate |
2013-02-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |