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publicationDate 2016-01-07-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber US-2016000935-A1
titleOfInvention Increasing tumor oxygenation for diagnostic assessments
abstract A method of assessing the susceptibility of a tumor to reduction in hypoxia, comprising delivering oxygen and CO 2 to attain a starting end tidal concentration of oxygen (PetO 2 ) between 350 and 450 mm Hg, and a starting end tidal concentration of CO 2 (PetCO 2 ) between 42 and 55 mm Hg; changing PetO 2 and/or PetCO 2 , wherein at least one increment of change is maintained for a time sufficient to obtain a surrogate measure of tumor oxygenation reflecting change in tumor oxygenation relative to a previously measured surrogate value of tumor oxygenation, wherein the starting PetO 2 and/or an incremental change in PetO 2 is approximately between 375 and 425 mm Hg, and wherein the starting PetCO 2 and/or an incremental change in PetCO 2 is approximately between 42 and 50 mm Hg; and obtaining a surrogate measure of tumor oxygenation after changing PetO 2 and/or PetCO 2 for comparison to a previously measured surrogate value of tumor oxygenation.
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