http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2015368314-A1

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filingDate 2015-09-08-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_92448ac64f759442dd7aa8aa57c14077
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b661872d81c012eadb46fc0837d5be93
publicationDate 2015-12-24-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber US-2015368314-A1
titleOfInvention Glucagon-like-peptide-2 (glp-2) analogues
abstract GLP-2 analogues are disclosed which comprise one of more substitutions as compared to [hGly2]GLP-2 and which improved biological activity in vivo and/or improved chemical stability, e.g., as assessed in in vitro stability assays. More particularly, preferred GLP-2 analogues disclosed herein comprise substitutions at one or more of positions 8, 16, 24 and/or 28 of the wild-type GLP-2 sequence, optionally in combination with further substitutions at position 2 (as mentioned in the introduction) and one or more of positions 3, 5, 7, 10 and 11, and/or a deletion of one or more of amino acids 31 to 33 and/or the addition of a N-terminal or C-terminal stabilizing peptide sequence. The analogues are particularly useful for the prophylaxis or treatment of stomach and bowel-related disorders and for ameliorating side effects of chemotherapy. Also disclosed are methods and kits for selecting a patient from populations suited for treatment with GLP-2 analogues.
priorityDate 2005-05-04-04:00^^<http://www.w3.org/2001/XMLSchema#date>
type http://data.epo.org/linked-data/def/patent/Publication

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http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID7892
http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID14017587
http://rdf.ncbi.nlm.nih.gov/pubchem/substance/SID226395485
http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID51381126
http://rdf.ncbi.nlm.nih.gov/pubchem/substance/SID226393750
http://rdf.ncbi.nlm.nih.gov/pubchem/substance/SID128787740
http://rdf.ncbi.nlm.nih.gov/pubchem/substance/SID226394204
http://rdf.ncbi.nlm.nih.gov/pubchem/substance/SID226396360
http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID14907381
http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID11025495
http://rdf.ncbi.nlm.nih.gov/pubchem/substance/SID226408336
http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID249332
http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID42890
http://rdf.ncbi.nlm.nih.gov/pubchem/substance/SID226403335

Total number of triples: 316.