http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2015368291-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_5ff4fc6caa37975b806f3313cae18215 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J63-008 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J53-002 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J53-00 |
| filingDate | 2015-01-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_03bfd59fc3eb4996aa8bf02dde84d0e0 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_464454f113b01f09e72aaa904210b6db http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_92ab8509a8206ef5d397c0ff8f50e829 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4f631bf4db7220aad1b04728a7a67a35 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_16e4109c5e960f43d7a29c87bc9b8b4e |
| publicationDate | 2015-12-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-2015368291-A1 |
| titleOfInvention | N-acetyl amino acid ESTER derivatives of Betulin and preparation method thereof |
| abstract | The present invention disclosed N-acetyl amino acid ester derivatives of betulin and the preparation method thereof, the method comprising the steps that in the presence of an alkaline substance, a catalyst and a racemization-inhibitor, the carboxyl group of N-acetyl amino acid is activated by a coupling agent; and then the activated N-acetyl amino acid is reacted with betulin via esterification reaction to obtain the N-acetyl amino acid ester derivative of betulin. The present invention provided a simple synthesis method to synthesize the N-acetyl amino acid ester derivatives of betulin by using betulin as a precursor compound and modifying the molecular structure of betulin. Such structural modification of betulin significantly enhances the anti-tumor activity of the betulin derivatives and therefore has important values. |
| priorityDate | 2014-06-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 146.