Predicate |
Object |
assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0e40d8e7082c36e138bed3476aaca4b3 |
classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2500-10 |
classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4184 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-40 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P15-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K45-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61N5-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-502 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-6872 |
classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61N5-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-40 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-68 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-50 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4184 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K45-06 |
filingDate |
2014-01-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9958fe05eb52e9701eb9d87735241340 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_10b38173a96d2b69efe5e1022b9d31fa |
publicationDate |
2015-12-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber |
US-2015355163-A1 |
titleOfInvention |
T-type calcium channel inhibitors for treatment of cancer |
abstract |
Presented herein are compounds that inhibit T-type Ca 2+ channel activity in a cell when the cell membrane potential is about −90 mV. Preferred compounds inhibit T-type Ca 2+ channel activity with an IC 50 of 10 μM or less at a membrane potential of about −90 mV. Preferred compounds show selectivity for inhibiting T-type Ca 2+ channel activity at about −90 mV, relative to inhibition of T-type Ca 2+ channel activity at about −30 mV to −60 mV, of 10:1 or less. Also provided are methods for identifying compounds that inhibit T-type Ca 2+ channel activity in a cell when the cell membrane potential is about −90 mV, and compounds identified by such methods. |
isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110742890-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2019008516-A3 |
priorityDate |
2013-01-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type |
http://data.epo.org/linked-data/def/patent/Publication |