| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_3438811768d5b0caa638b0c8f6c17a92 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-569
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-70
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-76
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-94
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-92
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-30
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-22
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-24 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-28
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-2875
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-6854
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-4283
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-28 |
| filingDate |
2015-04-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_099fe3faa466a60a5a17c0236068fec1
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6ef354a013526ab790217f7216293281
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ffb21a7bb14bc67bafc60101f4215d32
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_268d1085d92457c008b2d85858f3539c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cd4d82cf1a59a09ab9fa74a800e50502
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cdcc55b7d5cc33926c95000f3de7715f |
| publicationDate |
2015-12-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2015344568-A1 |
| titleOfInvention |
Techniques for predicting, detecting and reducing aspecific protein interference in assays involving immunoglobulin single variable domains |
| abstract |
This invention provides, and in certain specific but non-limiting aspects relates to: assays that can be used to predict whether a given ISV will be subject to protein interference as described herein and/or give rise to an (aspecific) signal in such an assay (such as for example in an ADA immunoassay). Such predictive assays could for example be used to test whether a given ISV could have a tendency to give rise to such protein interference and/or such a signal; to select ISV's that are not or less prone to such protein interference or to giving such a signal; as an assay or test that can be used to test whether certain modification(s) to an ISV will (fully or partially) reduce its tendency to give rise to such interference or such a signal; and/or as an assay or test that can be used to guide modification or improvement of an ISV so as to reduce its tendency to give rise to such protein interference or signal; methods for modifying and/or improving ISV's to as to remove or reduce their tendency to give rise to such protein interference or such a signal; modifications that can be introduced into an ISV that remove or reduce its tendency to give rise to such protein interference or such a signal; ISV's that have been specifically selected (for example, using the assay(s) described herein) to have no or low(er)/reduced tendency to give rise to such protein interference or such a signal; modified and/or improved ISV's that have no or a low(er)/reduced tendency to give rise to such protein interference or such a signal. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9573992-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11644471-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11192937-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11192938-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2022072888-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110461870-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110191896-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10858418-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9683045-B2 |
| priorityDate |
2011-06-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |