| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_60442fdc20fd71481fc3d6b8cdee2c31 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2201-023
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2021-058
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2015-1006
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2015-0053
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2201-068
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2201-06113
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2015-1413 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N21-658
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N15-1404
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N15-1429
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N15-1434
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N21-05 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N15-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N21-65 |
| filingDate |
2015-05-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_684e33f6899c4488db516c664c932485
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5c09c2ec33c134466e8b2223047a2c44
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3f7c68ef28274543eea5ba4fca0c49b6
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6b4029d522825d77c51e0f47b6b4b382 |
| publicationDate |
2015-11-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2015338348-A1 |
| titleOfInvention |
Ultrasensitive sers flow detector |
| abstract |
The invention provides an apparatus and methods for label-free, chemical specific detection in flow for high throughput characterization of analytes in applications such as flow injection analysis, electrophoresis, and chromatography. A surface-enhanced Raman scattering (SERS) flow detector capable of ultrasensitive optical detection on the millisecond time scale has been developed. The device employs hydrodynamic focusing to improve SERS detection in a flow channel where a sheath flow confines analyte molecules eluted from a capillary over a planar SERS-active substrate. Increased analyte interactions with the SERS substrate significantly improve detection sensitivity. Raman experiments at different sheath flow rates showed increased sensitivity compared with the modeling predictions, indicating increased adsorption. At low analyte concentrations, rapid analyte desorption is observed, enabling repeated and high-throughput SERS detection. The flow detector offers substantial advantages over conventional SERS-based assays such as minimal sample volumes and high detection efficiency. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10859499-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-102542469-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-114923863-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-114252429-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-115096871-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11573237-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11573236-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-20180127939-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10451593-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11474110-B2 |
| priorityDate |
2014-05-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |