abstract |
Disclosed herein are arylpyridinone compounds and compositions useful in the treatment of ITK mediated diseases, such as inflammation, having the structure of Formula (I): n n n n n n n n n n wherein Ar, R 2 , R 4 , R 5 , n and X are as defined in the detailed description. Methods of inhibition of ITK activity in a human or animal subject are also provided. |