| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d3d9f7d95f33d2f13b129a746fb7495c |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-141
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-532
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2320-10 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6834
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6825
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-111
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-11 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-11
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-68 |
| filingDate |
2015-04-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_81147a9edd08e0cf89d93248c98c773d |
| publicationDate |
2015-10-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2015307926-A1 |
| titleOfInvention |
Detection units and methods for detecting a target analyte |
| abstract |
The present application relates to detection units and methods for detecting one or more target analytes in a sample. The detection unit provides a first and second surface connected by a filament which is capable of binding the target analyte in the sample. Double-stranded DNA molecules are provided having a continuous strand and a discontinuous strand, and an active segment that is designed to hybridize to a target nucleic acid of interest, where the continuous strand has between 0 and 100 unpaired nucleotides in the active segment and the discontinuous strand has between 5 and 100 unpaired nucleotides at its 3′ end and/or its 5′ end. The unpaired nucleotides in the continuous strand can form a secondary structure, such as a loop. The methods provide for the detection of the target analyte through the generation of a detectable signal, such as supercoiling, following the binding of the target analyte to the filament and can be used to detect nucleic acids of interest including single nucleotide polymorphisms or somatic mutations. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9382578-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10031065-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9632033-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9719935-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2014099635-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2017151062-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2016349182-A1 |
| priorityDate |
2014-04-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |