abstract |
Hyperpolarized 1- 13 C-2-oxoglutarate as contrast agent in 13 C Magnetic Resonance diagnostic technique ( 13 C-MRI) for use in the diagnosis of cancer. In particular, upon administration of said 1- 13 C-2-oxoglutarate, signals of 1- 13 C-glutamate are detected. More in particular, different MR signals from 13 C nuclei are detected and compared, said comparison being useful to determine a difference between tumor and non-tumor tissues, to determine the aggressiveness of a tumor or the efficacy of an anti-tumor therapy. |