| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_9d6f7da1e425c8a3ef1da21e08f4c196 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L2430-38
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61F2002-444
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61F2002-445
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61F2002-4445
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61F2002-4435 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L27-44
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L27-3856
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L27-3886
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61F2-442
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L27-24
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L27-22
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L27-20
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L27-3817
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L27-3691
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K35-32
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L27-52
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L27-3658 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61L27-24
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61L27-22
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61L27-36
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61L27-44 |
| filingDate |
2015-05-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b2d15fa86385f24131f5bf5ec5df39d6
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_98859e8497b50ba52c9ea1332e5e2663
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_79cdb370cb214aa049451a30850b9d5e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3461e63fa2bf5329a37576e7d2be38aa |
| publicationDate |
2015-08-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2015238657-A1 |
| titleOfInvention |
Composite tissue-engineered intervertebral disc with self-assembled annular alignment |
| abstract |
The present invention relates to a tissue-engineered intervertebral disc (IVD) suitable for total disc replacement in a mammal and methods of fabrication. The IVD comprises a nucleus pulposus structure comprising a first population of living cells that secrete a hydrophilic protein and an annulus fibrosis structure surrounding and in contact with the nucleus pulposus structure, the annulus fibrosis structure comprising a second population of living cells and type I collagen. The collagen fibrils in the annulus fibrosis structure are circumferentially aligned around the nucleus pulposus region due to cell-mediated contraction in the annulus fibrosis structure. Also disclosed are methods of fabricating tissue-engineered intervertebral discs. |
| priorityDate |
2009-05-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |