| abstract |
Compounds of Formula I and Formula IA are inhibitors of dihydrofolate reductase and are suitable for use in compositions and methods for dihydrofolate reductase inhibition or, more specifically, treatment of a fungal infection, a bacterial infection or a protozoal infection, and, in specific embodiments, treatment of a fungal infection caused by C. albicans or C. glabrata : n n n n n n n n n n wherein R, R 1 , R 2 , R 3 , R 4 , A, B, E, V, W, X, Y and Z are as defined herein. |