| abstract |
The present invention provides a compound having the structure: n n n n n n n n n n n n wherein n X is a therapeutic agent containing at least one amine nitogen and the amine nitrogen on the therapeutic agent covalently bonds directly to carbon α; n Z is CH 3 or CF 3 ; n R 1 is —H, —NR 2 R 3 , —NH—C(═O)—R 4 , —NH—C(═O)—OR 4 , —CH 2 —C(═O)—NR 5 R 6 , —OR 7 , —CO 2 R 7 , C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, aryl, or heteroaryl,n wherein R 2 , R 3 , R 4 , R 5 , R 6 and R 7 are each, independently, —H, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, heteroalkyl, cycloalkyl, heterocyclyl, aryl, alkylaryl, heteroaryl, alkylheteroaryl, an amino acid or an oligopeptide;n wherein an amine of the amino acid or oligopeptide is substituted or unsubstituted; and n n n n is an integer from 0 to 6;n nor a diastereomer, enantiomer or pharmaceutically acceptable salt of the compound. |