http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2015224088-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_5dcc9892f06ed5cdaa892e2faaa52740 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_b7fbd403d57ad5c35d28e6c2e957521f http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_724c2f84cdda9cd191b74292348bf1d5 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1c8cbbf2290b3f3a9988da29598baa2c |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K45-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-428 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K45-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-428 |
| filingDate | 2015-02-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5393912162a6942fd10843181cb8eebc http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4de04a344d4054b34a3bafbe6a996088 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_91399616a7354de3acb5550c25d1b995 |
| publicationDate | 2015-08-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-2015224088-A1 |
| titleOfInvention | Methods of treatment of ischemia-induced angiogenesis and arteriogenesis |
| abstract | It has now been discovered that p53 is a potent inhibitor of angiogenesis and arteriogensis. Inhibition of p53 stimulates angiogenesis, arteriogenesis and improves perfusion in limbs. Therefore, methods are provided for treating diabetic-induced ischemia in a subject in need thereof comprising locally administering a therapeutically effective amount of one or more p53 molecule inhibitors or analogs and derivatives thereof to a site of ischemic tissue in the subject. Methods are provided for improving limb perfusion in a subject in need thereof comprising locally administering a therapeutically effective amount one or more p53 inhibitors together with a therapeutic agent or separately from the therapeutic agent to cells of a limb of a subject in need thereof. Methods are also provided for improving ischemia-induced angiogenesis and arteriogenesis in method of improving ischemia-induced angiogenesis in tissue of a limb comprising administering a therapeutically effective amount one or more p53 inhibitors individually or in combination with another therapeutic to a subject in need thereof. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11464773-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2022218674-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2020215091-A1 |
| priorityDate | 2014-02-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 368.